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Frank madeo curriculum vitae

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To improve support for screen readers, please open this link. End of this page section. Go to overview of page sections. Reduction of daily energy intake is considered to lead to health protective effects in various conditions such as diabetes and metabolic syndrome, neurodegeneration and even cancer. Intermittent or periodical fasting is a convenient alternative to conventional fasting regimens.
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Cellular aging & intracellular communication

Frank madeo curriculum vitae
Frank madeo curriculum vitae
Frank madeo curriculum vitae
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Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease.
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Professor Frank Madeo

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Thursday pmpm sign up via youcanbookme. Frank Matero received his education in anthropology, architectural preservation, and material conservation. As an educator and conservation practitioner, Matero has shaped architectural conservation discourse and practice in the US and abroad for over 35 years. He is founder and editor-in-chief of Change Over Time , the international journal on conservation and the built environment published by University of Pennsylvania Press. Throughout his career Matero has focused on the historical and material investigation of architectural technology and the implications of this approach for the interpretation and conservation of built heritage.
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